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KMID : 0380620220540040391
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 4 p.391 ~ p.397
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Antidiabetic effects of unripe black raspberry ethanol extracts in C57BL/6N db/db mice
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Choi Hye-Ran
Lee Su-Jung
Ryu Tae-Ho
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Abstract
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This study aimed to verify the antidiabetic effects of the unripe black raspberry extract (UBRE) in obese diabetic mice. For the experiment, animal model mice were divided into six groups: normal control, diabetic control, three experimental groups (treated with 75, 150, and 300 mg/kg single dose of UBRE), and a positive control (200 mg/kg metformin). The groups treated with 300 mg/kg UBRE and metformin had significantly reduced blood glucose and triglyceride levels in the diabetic mice compared to those in the vehicle control group. In addition, histopathological evaluation showed that UBRE increased the Langerhans area, cell number, and insulin concentration in the pancreatic islets of db/db mice. Therefore, UBRE exerts significant antidiabetic effects by decreasing the blood glucose and lipid levels, suggesting that it can be consumed as a functional diet for diabetic patients.
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KEYWORD
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diabetic mice, unripe black raspberry extracts, blood glucose, insulin, triglyceride
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